Microparticulate polyelectrolyte complexes for gentamicin transport across intestinal epithelia

Amino acid transport across mammalian intestinal and renal epithelia.

The transport of amino acids in kidney and intestine is critical for the supply of amino acids to all tissues and the homeostasis of plasma amino acid levels. This is illustrated by a number of inherited disorders affecting amino acid transport in epithelial cells, such as cystinuria, lysinuric protein intolerance, Hartnup disorder, iminoglycinuria, dicarboxylic aminoaciduria, and some other le...

A novel mechanism for salt and fluid transport across epithelia.

Some salt transporting epithelia can absorb inorganic ions from extremely low external concentrations. Salt depleted frogs, for example, can absorb sodium ions from freshwater at concentrations down to o-oi mM (Krogh, 1939) while freshwater mosquito larvae can maintain haemolymph sodium at 30 mM in external media containing as little as 1-55 x 10-3 mM sodium (Stobbart, 1974). The ability of the...

Electrolyte transport across isolated large intestinal mucosa.

CD23-mediated transport of IgE/immune complexes across human intestinal epithelium: role of p38 MAPK.

We previously reported that CD23/FcepsilonRII (low-affinity IgE receptor) is expressed on human intestinal epithelial cells and is responsible for transepithelial transport of IgE. In this study, we compared the transport of IgE with that of immune complexes in both the apical-to-serosal and the serosal-to-apical directions across HT29 epithelial cell layers and examined the effects of two p38 ...

Polyelectrolyte–protein complexes

The field of polyelectrolye–protein complexes is now benefiting from the convergence of three themes whose disciplinary distinctions formerly produced fragmentation. Theory and simulations, previously restricted to isotropic models of colloids and polyelectrolytes, are now taking into account the heterogeneity of charges in both macroions and providing far more realistic depictions of proteins....